ACKCSC CHARITABLE TRUST RESEARCH
GRANT STATUS REPORT DECEMBER 2009


The funding of these grants and all future grants is dependent on fundraising and donations through the generosity of Cavalier lovers everywhere.  Donations may be made and more informatiom may be found on the ACKCSC Charitable Trust  web site http://ackcscharitabletrust.org/ 

RESEARCH GRANTS FUNDED

1. 

Breed Health Survey – Purdue University 

 $22,002.24

2.

 

 

Evaluation of Objective Structural and Functional   Measurements for Predicting Clinical Disease Progression And Assessing Treatment in Cavalier King Charles Spaniels With Caudal Occipital Malformation Syndrome – Ohio State University.  Funded by the ACKCSC Charitable Trust.

$15,355.00

3.

The Effect of Chiari I Malformation on CSF Flow in Cavalier King Charles Spaniels. 
NC State University.  Funded by the ACKCSC Charitable Trust.

$20,000.00

4.

 

Alteration in Protein Expression in Canine Myxomatous Mitral  Valve Disease. 
University of Edinburgh, Scotland.  Donation to this research by the ACKCSC Charitable Trust.

$6,480.00 

5.

Diagnosis of Primary Secretory Otitis     Media In The Cavalier King Charles Spaniel.  Ohio State University.  Funded by the ACKCSC  Charitable Trust.

 $53,958.00

6.

Mitral Valve Disease in Cavalier King Charles Spaniels.  University of Pennsylvania. Note:  Research began Sept. 1, 2006 with funds from an anonymous donor of $80,000.00

$63,446.00

7. 

 

Characterization of the Canine Y  Chromosome: Identifyiing Genes that Cause Male Infertility.  Texas A & M University.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$ 500.00

8.

 

Investigation of Antigenic Causes of Vaccine Associated Allergic Reaction in Dogs.  Purdue University.  Funded in cooperation with AKC Canine Health Foundation And other Parent Clubs.

$500.00

9.

 

Identification of Genes Causing Chiari I Malformation with Syringomelia in the Cavalier King Charles Spaniel.  University of Montreal Funded in cooperation with the AKC Canine Health Foundation.

$25,000.00

10.

 

The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma. North Carolina State University.  Funded in Cooperation with the AKC Canine Health Foundation and otherParent Clubs.

$2,500.00

11. 

 

Molecular Characterization of Valvular Interstatial Cells in Canine Chronic Valvular Disease.  Washington State University  Funded in Cooperation With the AKC Canine Health Foundation and other Parent Clubs

$2,500.00

12.

The Rabies Challenge Fund.  Donation from the ACKCSC Charitable Trust.

$3,000.00

13.

 

Evaluation of Novel Diagnostic and therapeutic Modalities  for Treatment of Canine Pulmonary Hypertension.  University of Missouri.   Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$1,000.00 

14.

 

 

 

Syringomyelia in the Brussels Griffon:  Magnetic Resonance Imaging   FIndings, Clinicopathology, and Prevalence.  University of Georgia.  Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs.

Although this research is for Brussels Griffons, the Trustees believe that   anything we can learn from any research on SM may also be useful to  Cavaliers.  The findings in this study of similarities or differences may be helpful in our future SM research.

$5,000.00

15.

 

 

 

 

Evaluation of Multidrug Resistance Genes in Primary Canine Lymphoma  Cells Exposed to Enrofloxacin and Predisolone. This research may result in  changes in the management of patients with lymphoma or suspected lymphoma  regarding steroid and antibiotic treatment.  Auburn University.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs

Based on our Health Survey done in 2004 – 2005, cancer was the number two cause of death in Cavaliers.  The Trustees believe that cancer research is very  important to our breed

$500.00

16.

 

Investigation of NF-kB as aTherapeutic Target in Canine Lymphoma.      University of Pennsylvania – School of Veterinary Medicine.  Funded in  cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$500.00

17.

 

Development of a Diagnostic Method for Canine Atopic Dermatitis.   This research hopes to develop a simple blood test to detect whether or not  particular dog is hyper-reactive to its own immune cells.  Imulan Bio Therapeutics.Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs.

$500.00

18.

 

Comparison of percentage of T regulatory cells in dogs with spontaneously  occurring lymphoma following oral versus intravenous cyclophosphamide.University of Missouri, Columbia.  Funded in cooperation with the AKCCanine Health Foundation and other Parent Clubs.

$500.00

19.

 

Heritable and Sporadic Genetic Lesions in Canine Lymphoma.  This research will set the groundwork to identify specific genes associated   with breed-dependent cancer risk.  North Carolina State University. Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs

$2,500.00

20.

 

 

A collaborative study by Veterinary Oncologists, Pathologists and  Diagnostic Laboratories to Enhance the Detection, Diagnosis and Treatment  of Canine Lymphoma.  This research will alter costs of treatment according  to tumor type and increase survival.  University of Illinois.  Funded in Cooperation with the AKC Canine Health Foundation and other
Parent Clubs

$1,000.00 

21

 

.

Seratonin Type2A Receptor Antagonist Therapy for Preventing  the Progression of Myxomatous Mitral Valve Disease.  This proposal   represents a novel translational study that targets a potential underlying   pathogenesis of canine mitral valve disease.  University of Pennsylvania –School of Veterinary Medicine.  Funded in cooperation with the AKC
Canine Health Foundation and other Parent Clubs.

$5,000.00 

22.

 

 

Effect of Treatment with Low Doses of Hydrocortisone on Blood Pressure and Mortality in Dogs with Septic Shock.
University of California, Davis – School of Veterinary Medicine. Funded in cooperation with the AKC Canine Health Foundation And other Parent Clubs.

$500.00

23.

 

 

Tissue Regeneration using Canine Mesenchymal Stem Cells:   Effects of Donor Characteristics and ex vivo Expansion on Cell Pluripotency.  This research will bring promising stem cell therapies closer to reality in veterinary medicine including new therapies for heart failure.  University of Pennsylvania – School of Veterinary Medicine.  Funded in cooperation With the AKC Canine Health Foundation and other Parent Clubs

$2,500.00

24.

 

 

Prevalence and Localization of Bartonella spp. In Vascular Tumors from Dogs.  This research will facilitate the  development of tests that can be used to establish the cellular localization  of Bartonella in the diseased tissues of infected dogs.  North Carolina State University.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$1,000.00

25.

 

 

Detection of Brucella canis DNA in canine urine,  semen and vaginal cells via qPCR Analysis.  Currently there is no early  detection testing available for this disease.  This research hopes to develop  a test that will detect the disease earlier than traditional culture and serology. Iowa State University.  Funded in cooperation with the AKC Canine
Health Foundation and other Parent Clubs

$500.00

26

 

Investigation of the presence of Chiari-like malformation and  syringomelia in stillborn Cavalier King Charles Foetuses.     The Royal Veterinary College, U.K.  Donation by the ACKCSC  Charitable Trust.

$15,000.00 

 

 

 

 

 

 

 

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